01410nas a2200241   4500000000100000008004100001653002000042653001200062653002600074653003000100653002100130653002300151100001300174700001500187700001500202700001400217245006200231856006100293300000800354490000700362050001600369520078300385       2013                            d10aType 1 reaction10aleprosy10aIntra-granuloma edema10aHypersensitivity reaction10aDermatopathology10aBorderline leprosy1 aThomas M1 aPonnaiya J1 aEmmanuel M1 aRichard J00aType I reaction in leprosy : A histopathological analysis  uhttp://www.ijl.org.in/oct-dec/1%20Thomas%20(1-4)%20f.pdf  a1-40 v85  aTHOMAS 20133 aEven though type 1 lepra reaction (TIR) is a commonly encountered clinical problem, its histology has not yet
been clearly delineated. This study attempts to enumerate the most sensitive parameters for the histological
diagnosis of TIR. Case records between March 2007 and September 2007 of patients with TIR were reviewed
and the biopsies were evaluated by a pathologist blinded to the previous diagnoses. Twenty three patients
were included in the study. The most sensitive parameters in our study were dermal edema, intra-granuloma
edema and giant cell size. Though clinical findings should remain the mainstay of diagnosis of TIR, the above
mentioned parameters should be evaluated in biopsies of leprosy to look for signs of reaction which might
otherwise be missed.