02335nas a2200361   4500000000100000008004100001260000900042653001200051653001300063653002700076653001200103653002600115653000900141653002400150653001600174653001900190653001700209653002200226653000900248653001700257653003300274100001700307700001500324700001900339700001400358700001300372700001300385245009700398300001200495490000700507520144500514022001401959       2013                            d  c201310aAnimals10aCocculus10aDisease Models, Animal10aEthanol10aKidney Function Tests10aMale10aMedicine, Ayurvedic10aNephrectomy10aPlant Extracts10aPlant Leaves10aProtective Agents10aRats10aRats, Wistar10aRenal Insufficiency, Chronic1 aGadapuram TK1 aMurthy JSN1 aRajannagari RR1 aKandati V1 aChoda PK1 aShukla R00aNephroprotective activity of Cocculus hirsutus leaf extract in 5/6 nephrectomized rat model.  a299-3060 v243 a<p><b>BACKGROUND: </b>Cocculus hirsutus, commonly known as broom creeper, belongs to the family Menispermaceae. It is widely used in folk medicine to treat leprosy, skin diseases, dyspepsia, etc. Hence, an effort has been made to investigate the nephroprotective potential of C. hirsutus.</p><p><b>METHODS: </b>The nephroprotective activity of ethanolic C. hirsutus leaf extract (ECHE) in the 5/6 nephrectomized rat model was investigated. Different parameters like postoperative survival rate, change in body weight and levels of red blood corpuscles (RBCs), hemoglobin (Hb), triglyceride, cholesterol, creatinine, urea and uric acid were estimated in experimental rats.</p><p><b>RESULTS: </b>The findings revealed the postoperative survival rate of rats in the investigated novel method to be 100%. Change in the body weight of ECHE-treated groups I and II was found to be 32 and 30 g, respectively. These values suggested that ECHE treatment normalized the elevated body weight levels in experimental rats. Furthermore, ECHE treatment normalized the decreased RBC levels and the elevated Hb, triglyceride, cholesterol, creatinine, urea and uric acid levels in experimental rats.</p><p><b>CONCLUSIONS: </b>The results indicate that C. hirsutus has strong nephroprotective activity. However, further scrutiny is essential for isolation and characterization of the active components that can be employed to allay various human maladies.</p>  a2191-0286