01187nas a2200229   4500000000100000008004100001653001200042653002100054653001400075653001700089653001400106653001200120100001300132700001100145700001300156245009500169856007400264300001200338490000600350050001400356520058700370       2013                            d10aleprosy10aHypersensitivity10aHepatitis10aEosinophilia10aDrug rash10aDapsone1 aVinod KV1 aArun K1 aDutta TK00aDapsone hypersensitivity syndrome: A rare life threatening complication of dapsone therapy  uhttp://www.lepra.org.uk/platforms/lepra/files/lr/Dec12/Lep370-377.pdf  a158-1600 v4  aVINOD20133 aDapsone can cause several adverse effects, the most serious being dapsone hypersensitivity syndrome (DHS), which is potentially fatal. Here we report a case of severe, life threatening dapsone systemic hypersensitivity syndrome in a 17-year-old male who presented with high grade fever, eosinophilia, lymphadenopathy, skin rash, hepatitis and encephalopathy, which was managed successfully with oral steroids. The case is being reported to emphasize the need for timely diagnosis and prompt treatment of this rare complication for successful outcomes. DHS is also reviewed in brief.