01994nas a2200313   4500000000100000008004100001260001200042653001500054653001200069653001400081100001600095700001400111700001600125700001700141700001600158700002400174700001400198700001300212700001300225700001500238700001800253700002200271245011600293856007100409300000900480490001900489520115800508022001401666       2012                            d  c10/201210aMICA genes10aleprosy10aHLA genes1 aJarduli L R1 aAlves H V1 aDesouza F C1 aMarcos E V C1 aPEREIRA A C1 aDias-Baptista I M F1 aRamos G B1 aFava V M1 aMira M T1 aMoraes M O1 aVirmond Mda C1 aVisentainer J E L00a168-P: ASSOCIATION OF HLA AND MICA ALLELES WITH LEPROSY IN FAMILIES FROM AN ENDEMIC AREA OF THE NORTH OF BRAZIL  uhttp://www.sciencedirect.com/science/article/pii/S0198885912004594  a153 0 v73, Supplement3 a<p>Aim The objective of this study was to evaluate the influence of HLA and MICA alleles in the development of leprosy and its clinical forms in a population with leprosy from the region of Santo Antônio do Prata – PA, Brazil. Methods Fifty-one families were genotyped for HLA and MICA genes by PCR-SSOP, LuminexÒ methodology (One Lambda) and Dynal AutoRELITM 48 Instrument (Invitrogen) Dynal-RELITMSSO HLA Typing. Statistical Analysis was based on the Transmission Disequilibrium Test (TDT) software FBAT 2.0.4. Results The alleles HLA-A∗03/11 (P=0.041), HLA-C∗04 (P=0.025), HLA-DRB1∗16 (P=0.048), DQB1∗05 (P=0.004) and MICA∗002 (P = 0.003) showed significant positive association with the occurrence of leprosy in this population, while the alleles HLA-C∗12 (P = 0.095), DRB1∗15/16 (P = 0.055), and MICA∗008 (P = 0.075) showed a tendency to positive association. Conclusions This study suggests that the alleles HLA-A∗03/∗11, HLA-C∗04, HLA-DRB1∗16, DQB1∗05 and MICA∗002 may be associated with susceptibility to leprosy in this population and HLA-C∗12, DRB1∗15/16 and MICA∗008 should be further investigated.</p>
  a0198-8859