01805nas a2200313   4500000000100000008004100001260001300042653002100055653001300076653001100089653001000100653001200110653002700122653002100149653002500170653003600195100001400231700001500245700001700260700001800277700001200295700001500307245013900322856008600461300001200547490000700559520091100566022001401477       2013                            d  c2013 Nov10aEndemic Diseases10agenotype10aHumans10aIndia10aleprosy10aMolecular Epidemiology10aMolecular Typing10aMycobacterium leprae10aPolymorphism, Single Nucleotide1 aLavania M1 aJadhav R S1 aTurankar R P1 aChaitanya V S1 aSingh M1 aSengupta U00aSingle nucleotide polymorphisms typing of Mycobacterium leprae reveals focal transmission of leprosy in high endemic regions of India.  uhttp://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)63009-3/pdf  a1058-620 v193 a<p>Earlier studies indicate that genotyping of Mycobaterium leprae based on single-nucleotide polymorphisms (SNPs) is useful for analysis of the global spread of leprosy. In the present study, we investigated the diversity of M. leprae at eight SNP loci using 180 clinical isolates obtained from patients with leprosy residing mainly in Delhi and Purulia (West Bengal) regions. It was observed that the frequency of SNP type 1 and subtype D was most predominant in the Indian population. Further, the SNP type 2 subtype E was noted only from East Delhi region and SNP type 2 subtype G was noted only from the nearby areas of Hoogly district of West Bengal. These results indicate the occurrence of focal transmission of M. leprae infection and demonstrate that analysis by SNP typing has great potential to help researchers in understanding the transmission of M. leprae infection in the community. </p>  a1469-0691