01449nas a2200265   4500000000100000008004100001260001300042653001600055653002600071653001100097653002600108653002300134653002500157653002200182653001200204100001400216700001400230245008200244856007900326300001100405490000800416050001700424520072800441022001401169       2013                            d  c2013 May10aBCG Vaccine10aHistory, 20th Century10aHumans10aImmunotherapy, Active10aLeprostatic Agents10aLeprosy, lepromatous10aMilitary Medicine10aVietnam1 aChastel C1 aChastel A00a[About a note published in 1926 on a BCG vaccine trial in leprosy treatment].  uhttps://bspe.revuesonline.com/gratuit/BSPE106_2_13149_2013_Article_280.pdf  a126-300 v106  aCHASTEL 20133 a<p>By 1926, two French physicians working in Indochina, R. Pons and L. Chastel, have suggested to treat leprosy by subcutaneous injections of bacillus Calmette-Guerin. This treatment appeared efficient since the lepromatous lesions quickly regressed and the Hansen bacillus disappeared from the nasal mucus. These results were quickly confirmed by other authors. They were all more appreciated than, at this time, the Chaulmoogra oil and its products, the only available drugs, were poorly efficient against the disease. Nevertheless, although not a panacea, the BCG therapy allowed to relieve these unfortunate patients until the beginning of the 1950's when an effective treatment by sulfones was at length available.</p>  a1961-9049