02745nas a2200457   4500000000100000008004100001260001300042653001000055653001100065653003000076653002100106653001100127653001100138653001400149653002600163653002300189653002800212653002000240653000900260653001600269653002500285653001300310653002200323653001500345653001700360653002200377653003000399100001400429700002200443700001500465700001100480700001700491700001300508245016200521856005000683300001100733490000700744050001500751520150700766022001402273       2012                            d  c2012 Sep10aAdult10aBrazil10aDrug Therapy, Combination10aErythema Nodosum10aFemale10aHumans10aIncidence10aKaplan-Meier Estimate10aLeprostatic Agents10aLeprosy, Multibacillary10aLogistic Models10aMale10aMiddle Aged10aMycobacterium leprae10aNeuritis10aPeripheral nerves10aRecurrence10aTime Factors10aTreatment Outcome10aWorld Health Organization1 aPenna MLF1 aBührer-Sékula S1 aPontes MAA1 aCruz R1 aGonçalves H1 aPenna GO00aPrimary results of clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): reactions frequency in multibacillary patients.  uhttps://leprosyreview.org/article/83/3/00-308  a308-190 v83  aPENNA 20123 a<p><b>SETTINGS: </b>Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment, allowing for uniform treatment for all cases, makes case classification superfluous and therefore simplifies leprosy control.</p><p><b>OBJECTIVE: </b>To evaluate the association of the treatment duration with the frequency of reactions among MB patients.</p><p><b>METHODS: </b>An open-label randomised clinical trial to compare the present routine treatment with one lasting six months. Patients were recruited between March 2007 and February 2012. We analysed the frequency of first reaction with the Kaplan-Meier method and of recurrent reaction with a Poisson regression, using the treatment group and baciloscopic index level (BI) as independent variables. Logistic regression was used to evaluate the statistical association of different reaction types and the treatment group.</p><p><b>RESULTS: </b>Among those with BI < 3, we found a statistical significant difference of reaction frequencies between the treatment groups from 6 to 18 months since the beginning of treatment. This difference disappears at 2 years after the start of treatment. Multiple reactions were associated with the treatment group and with BI > or = 3. No specific types of reactions were associated with treatment duration.</p><p><b>CONCLUSION: </b>Although this is the first report of U-MDT/CT-BR, the results presented here support the possibility of use of UMDT in the field.</p>  a0305-7518