01505nas a2200253   4500000000100000008004100001260001300042653002500055653001200080653002400092100001700116700002100133700001500154700001900169700001200188700001900200700001800219700002200237245007000259300001100329490000700340520089000347022001401237       2013                            d  c02/2013 10aNetherton's syndrome10aleprosy10alepromatous leprosy1 aOliveira F L1 aVasconcellos B O1 aMorais T S1 aNascimento M B1 aTeles R1 aCosta Nery J A1 aMiranda M J S1 aAzulay-Abulafia L00aNetherton's syndrome and lepromatous leprosy: a mere coincidence?  a186-900 v523 aObjectives  Netherton's syndrome (NS) is a rare autosomal recessive condition, first described in 1958, which involves a complex immunological dysfunction, ichthyosiform dermatitis, and erythroderma, characteristic defects of the hair shaft and atopy. Recurrent bacterial infection in the skin of patients with NS is frequent. Methods  This paper represents the first case report of leprosy and concurrent NS. Discussion  This case merits discussion among doctors in endemic and non-endemic areas to evaluate the chronic use of systemic corticosteroids as a risk factor for leprosy. The present patient came from an endemic area of leprosy and was treated chronically with systemic corticosteroids for erythroderma. This treatment, along with the immunodeficiency related to the syndrome and caused by a genetic mutation in SPINK5, may be a facilitating factor for the infection.  a1365-4632