01742nas a2200205   4500000000100000008004100001653001600042653002200058653001200080653002000092653001000112100001400122700001400136245003300150856005300183300001100236490000700247050001500254520126700269       2012                            d10aROM therapy10aMultidrug therapy10aleprosy10aHistoid leprosy10aEgypt1 aBakry O A1 aAttia A M00aHistoid leprosy: Case report  uhttp://adc.mef.hr/index.php/adc/article/view/736  a256-590 v20  aBAKRY 20123 aHistoid leprosy is a rare but well-defined entity with specific clinical, histopathologic, and bacteriologic features. We present a case of histoid leprosy in an 84-year-old Egyptian male in view of the rarity of this condition. The patient presented with erythematous itchy discrete and coalescent papules that were distributed bilaterally and symmetrically on the front and back of the trunk. Before approaching us, he was initially misdiagnosed as a case of pityriasis rosea. There was no mucosal or facial affection and the patient’s general examination was normal. Routine hematologic investigations, urine analysis, liver and renal function tests were all normal. Slit skin smear revealed acid-fast bacilli of BI - 6+ and MI - 50-60%. Histopathologic examination of hematoxylin and eosin-stained section revealed atrophic epidermis with flattened rete ridges and dermal infiltration by nodular granulomata formed of spindle shaped histiocytes with pyknotic nuclei oriented in a storiform pattern. Fite’s stain for lepra bacilli showed plenty of acid fast bacilli. So, the diagnosis of histoid leprosy was made. Therefore, ROM therapy (rifampicin 600 mg, ofloxacin 400 mg, minocycline 200 mg) was started and followed by multi-drug
therapy for 2 years.