02684nas a2200445 4500000000100000008004100001260001300042653001500055653001000070653000900080653001200089653001100101653002500112653001000137653001100147653001900158653003800177653002000215653001100235653001200246653001500258653000900273653001600282653001600298100001700314700001500331700002600346700001300372700001300385700001700398700001500415700002000430245014900450856004800599300001000647490001600657050001600673520153500689022001402224 2012 d c2012 Dec10aAdolescent10aAdult10aAged10aAlleles10aBrazil10aCase-Control Studies10aChild10aFemale10aGene Frequency10aGenetic Predisposition to Disease10aHLA-DRB1 Chains10aHumans10aleprosy10aLeukocytes10aMale10aMiddle Aged10aYoung Adult1 aCorrêa RGCF1 aAquino DMC1 aJesus Mendes Caldas A1 aSerra HO1 aSilva FF1 aFerreira MJC1 aSantos EJF1 aMesquita ERRBPL00aAssociation analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil. uhttp://www.scielo.br/pdf/mioc/v107s1/22.pdf a150-50 v107 Suppl 1 aCORREA 20123 a
Epidemiological studies have demonstrated that the variability of the clinical response to infection caused by Mycobacterium leprae is associated with host genetic factors. The present study investigated the frequency of human leukocyte antigen (HLA) class II (DRB1) alleles in patients with leprosy from São Luís, Maranhão, Brazil. A case-control study was performed in 85 individuals with leprosy and 85 healthy subjects. All samples were analysed via polymerase chain reaction-sequence specific oligonucleotide probes. The HLA-DRB1*16 allele showed a higher frequency in the group with leprosy [(9.41% vs. 4.12%) odds ratio (OR) = 2.41 95% confidence interval (CI) (0.96-6.08) p = 0.05], whereas the HLA-DRB1*11 allele was less frequent in the group with leprosy [(6.47% vs. 11.76%) OR = 0.51 95% CI (0.23-1.12) p = 0.09]. The frequency of HLA-DRB1* alleles between the control group and leprosy patient subgroups presenting different forms of the disease showed that the HLA-DRB1*16 (16.13% vs. 8.24%, OR = 4.10, CI = 1.27-13.27, p = 0.010) and HLA-DRB1*14 (5% vs. 3.53%, OR = 4.63, CI = 1.00-21.08, p = 0.032) alleles were significantly more frequent in patients with different clinical subtypes of leprosy. The sample size was a limitation in this study. Nevertheless, the results demonstrated the existence of a genetic susceptibility associated with the clinical forms of leprosy. The low frequency of the HLA-DRB1*11 allele should be further studied to investigate the possible protective effect of this allele.
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