02326nas a2200349   4500000000100000008004100001260001300042653003000055653001100085653002200096653001100118653001400129653002300143653001200166653000900178653001900187653001500206653001600221653001400237653001300251653002200264100001400286700001200300700001100312245004400323856005900367300002800426490001300454050003200467520146300499022001401962       2000                            d  c2000 Dec10aDrug Therapy, Combination10aFemale10aFollow-Up Studies10aHumans10aIncidence10aLeprostatic Agents10aleprosy10aMale10aMass Screening10aMicronesia10aMinocycline10aOfloxacin10aRifampin10aTreatment Outcome1 aDiletto C1 aBlanc L1 aLevy L00aLeprosy chemoprophylaxis in Micronesia.  uhttp://leprev.ilsl.br/pdfs/2000/v71s1/pdf/v71s1a04.pdf  aS21-3; discussion S24-50 v71 Suppl  aInfolep Library - available3 a<p>A programme of chemoprophylaxis was introduced as a component of the leprosy control programme in the Federated States of Micronesia (FSM), beginning in 1996. The entire population of the country was to be screened, and a single dose of 600 mg rifampicin, 400 mg ofloxacin and 100 mg minocycline (ROM) was to be administered to the entire population. Two rounds of screening the entire population were carried out, approximately 1 year apart, and chemoprophylaxis was administered at the time of each screening. Ninety percent of the population were screened at least once, and 55% were screened in both rounds; 87% of the population received at least one dose, and 54% received two doses. In the course of the first round, 322 new cases were detected, whereas only 80 new cases were detected during the second round, of whom only 12 had received chemoprophylaxis in the course of the first round. A third round of screening, confined to a small number of villages in both Chuuk and Pohnpei, in which states leprosy endemicity was high, was carried out approximately 2 years after the second. Only 16 new cases were detected during the third round of screening, whereas 102 new cases had been detected in this same population during the first round of screening, and 32 new cases during the second. Six of the 16 newly detected cases stated that they had been administered chemoprophylaxis at least once; however, this information may not be reliable.</p>  a0305-7518