02084nas a2200541   4500000000100000008004100001260001200042653001200054653003200066653002300098100001000121700001400131700001100145700000900156700000900165700000900174700001000183700001000193700000900203700001000212700001100222700001000233700001100243700000900254700001000263700001000273700000900283700001000292700001000302700001000312700000900322700001200331700001100343700001100354700001000365700000900375700001100384700001100395700001100406700001200417700001000429700001200439245014700451300001300598490000700611520091000618022001401528       2012                            d  c11/201210aleprosy10aInflammatory Bowel Diseases10ainfectious disease1 aLiu H1 aIrwanto A1 aTian H1 aFu X1 aYu Y1 aYu G1 aLow H1 aChu T1 aLi Y1 aShi B1 aChen M1 aSun Y1 aYuan C1 aLu N1 aYou J1 aBao F1 aLi J1 aLiu J1 aLiu H1 aLiu D1 aYu X1 aZhang L1 aYang Q1 aWang N1 aNiu G1 aMa S1 aZhou Y1 aWang C1 aChen S1 aZhang X1 aLiu J1 aZhang F00aIdentification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases  a935 - 410 v913 aOf eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10−19; odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10−18; OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.  a0002-9297