02614nas a2200709   4500000000100000008004100001260001600042653001000058653000900068653002200077653002500099653001100124653003800135653001100173653003200184653002100216653003100237653004200268653001200310653000900322653001600331653003600347100001000383700001400393700001100407700000900418700000900427700000900436700001000445700001000455700000900465700001000474700001100484700001000495700001100505700000900516700001000525700001000535700000900545700001000554700001000564700001000574700000900584700001200593700001100605700001100616700001000627700000900637700001100646700001100657700001100668700001200679700001000691700001200701245014800713856008100861300001100942490000700953050001300960520091700973022001401890       2012                            d  c2012 Nov 0210aAdult10aAged10aAged, 80 and over10aCase-Control Studies10aFemale10aGenetic Predisposition to Disease10aHumans10aInflammatory Bowel Diseases10aInterferon-gamma10aInterleukin-12 Subunit p4010aInterleukin-18 Receptor alpha Subunit10aleprosy10aMale10aMiddle Aged10aPolymorphism, Single Nucleotide1 aLiu H1 aIrwanto A1 aTian H1 aFu X1 aYu Y1 aYu G1 aLow H1 aChu T1 aLi Y1 aShi B1 aChen M1 aSun Y1 aYuan C1 aLu N1 aYou J1 aBao F1 aLi J1 aLiu J1 aLiu H1 aLiu D1 aYu X1 aZhang L1 aYang Q1 aWang N1 aNiu G1 aMa S1 aZhou Y1 aWang C1 aChen S1 aZhang X1 aLiu J1 aZhang F00aIdentification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases.  uhttp://download.cell.com/AJHG/pdf/PIIS0002929712005137.pdf?intermediate=true  a935-410 v91  aLIU 20123 a<p>Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.</p>  a1537-6605