01544nas a2200325   4500000000100000008004100001260001700042653002700059653001200086653000900098653001100107653002300118653001200141653002900153653000900182653002500191653002200216100001400238700001300252700001400265700001500279700001500294700001500309245021900324300001100543490000700554050003200561520061100593022001401204       2000                            d  c2000 Oct-Dec10aAdenosine Triphosphate10aAnimals10aFoot10aHumans10aLeprostatic Agents10aleprosy10aLuminescent Measurements10aMice10aMycobacterium leprae10aTreatment Outcome1 aGupta U D1 aKatoch K1 aSingh H B1 aNatrajan M1 aSharma V D1 aKatoch V M00aAssessment of viability by normal mouse foot-pad and bacillary ATP bioluminescence assay in multibacillary cases treated with an MDT regimen using conventional as well as newer drugs like minocycline and ofloxacin.  a437-420 v72  aInfolep Library - available3 a<p>The therapeutic effect of a drug regimen of conventional drugs as well as newer drugs like ofloxacin and minocycline in smear-positive multibacillary (MB) leprosy cases was assessed by mouse foot-pad and ATP bioluminiscence methods. Biopsies were taken before starting treatment and after one year of treatment. They were processed for viability assessment by normal mouse foot-pad inoculation and bacillary ATP assay techniques. The test regimen was quite effective in its anti-bacterial effect as it was found to result in loss of bacillary viability in all the cases, as assessed by both methods.</p>  a0254-9395