01517nas a2200325   4500000000100000008004100001260001700042653003100059653001000090653002600100653003000126653001100156653001700167653001100184653002300195653002500218653000900243653002500252653001700277100001600294700001500310700001700325700001400342245006400356300001000420490000700430050003200437520070800469022001401177       2000                            d  c2000 Oct-Dec10aAdministration, Intranasal10aAdult10aAnti-Bacterial Agents10aDrug Therapy, Combination10aFemale10aFusidic Acid10aHumans10aLeprostatic Agents10aLeprosy, lepromatous10aMale10aMycobacterium leprae10aNasal Mucosa1 aMahajan P M1 aJadhav V H1 aJogaikar D G1 aMehta J M00aIntranasal administration of fusidic acid cream in leprosy.  a451-50 v72  aInfolep Library - available3 a<p>The effect of local treatment of nostrils with fusidic acid cream was investigated in 30 previously untreated lepromatous leprosy patients. The cream was applied in the nostrils after flushing the nostrils with normal saline, twice a day for a period of four weeks. It was found that 20 mg/gm of sodium fusidate was effective in reducing the morphological index of the nose-blow smear to zero in two weeks in majority of the patients. No untoward side effect was seen in any of the patients. Such nasal treatment along with multidrug therapy may help in reducing the patient's level of infectiousness to their contacts, since the nose is recognized to be an important portal of exit of M. leprae.</p>  a0254-9395