01443nas a2200217   4500000000100000008004100001260001200042653002200054653002100076653001200097653002500109100001400134700001300148700001300161245005800174856008800232300001200320490000600332050001700338520087000355       2011                            d  c10/201110aProtein oxidation10aProtein carbonyl10aleprosy10aAntioxidant vitamins1 aAsalkar A1 aGirish S1 aNaoley R00aProtein oxidation and antioxidant vitimins in leprosy  uhttp://ijpsr.com/bft-article/protein-oxidation-and-antioxidant-vitamins-in-leprosy/  a2870-730 v2  aASALKAR 20113 a<p>Aims The presence of carbonyl groups in proteins has been used as a marker of ROS-mediated protein oxidation. The present work was undertaken to study the importance of endogenous antioxidants like Vitamin C and vitamin E in different types of leprosy patients. Methods: Total 30 leprosy cases were studied. Patients were subjected to various tests like, serum protein carbonyl as an index of protein oxidation, while serum Vitamin C and Vitamin E levels as endogenous antioxidants. Results: An increased level of protein carbonyl indicates oxidative stress .The levels of Vitamins C, E decreased significantly in leprosy. Conclusions: Protein carbonyl can be used as sensitive indicator of oxidative stress in leprosy patients. Vitamin C and vitamin E can be supplemented along with anti-leprosy drugs to control the protein oxidation in leprosy patients.</p>