01950nas a2200313   4500000000100000008004100001260001200042653001500054653001200069653001000081100001700091700001200108700001000120700001300130700001900143700001200162700001300174700001000187700001300197700001100210700001100221700001700232245011600249856007100365300000900436490001900445520115800464022001401622       2012                            d  c10/201210aMICA genes10aleprosy10aHLA G1 aVisentainer 1 aMoraes 1 aMira 1 aPEREIRA 1 aDias-Baptista 1 aMarcos 1 aDesouza 1 aFava 1 aJarduli 1 aAlves 1 aRamos 1 aVirmond Mda 00a168-P: ASSOCIATION OF HLA AND MICA ALLELES WITH LEPROSY IN FAMILIES FROM AN ENDEMIC AREA OF THE NORTH OF BRAZIL  uhttp://www.sciencedirect.com/science/article/pii/S0198885912004594  a153 0 v73, Supplement3 a<p>Aim The objective of this study was to evaluate the influence of HLA and MICA alleles in the development of leprosy and its clinical forms in a population with leprosy from the region of Santo Antônio do Prata – PA, Brazil. Methods Fifty-one families were genotyped for HLA and MICA genes by PCR-SSOP, LuminexÒ methodology (One Lambda) and Dynal AutoRELITM 48 Instrument (Invitrogen) Dynal-RELITMSSO HLA Typing. Statistical Analysis was based on the Transmission Disequilibrium Test (TDT) software FBAT 2.0.4. Results The alleles HLA-A∗03/11 (P=0.041), HLA-C∗04 (P=0.025), HLA-DRB1∗16 (P=0.048), DQB1∗05 (P=0.004) and MICA∗002 (P = 0.003) showed significant positive association with the occurrence of leprosy in this population, while the alleles HLA-C∗12 (P = 0.095), DRB1∗15/16 (P = 0.055), and MICA∗008 (P = 0.075) showed a tendency to positive association. Conclusions This study suggests that the alleles HLA-A∗03/∗11, HLA-C∗04, HLA-DRB1∗16, DQB1∗05 and MICA∗002 may be associated with susceptibility to leprosy in this population and HLA-C∗12, DRB1∗15/16 and MICA∗008 should be further investigated.</p>
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