01825nas a2200289   4500000000100000008004100001260001300042653001200055653003100067653001600098653002500114653001900139653003100158653001100189653001000200653001000210653001200220653000900232653002700241653002500268100001500293245007500308300001000383490000700393520112100400022001401521       2012                            d  c2012 Sep10aAnimals10aBacteriological Techniques10aBCG Vaccine10aCooperative Behavior10aDrug Discovery10aDrug Resistance, Bacterial10aHumans10aJapan10aKorea10aleprosy10aMice10aMolecular Epidemiology10aMycobacterium leprae1 aMatsuoka M00a[Collaboration between Korea and Japan for basic research on leprosy].  a205-70 v813 a<p>New case detection in Japan has been markedly decreased and same trends have been also shown in Korea. Despite of unfavorable circumstances, research activities are still continuing and we have the accumulation of knowledge on leprosy both in Japan and Korea. Following basic studies for leprosy on going in Japan were reviewed. 1. Analysis of drug resistance mechanism and its application for clinical samples. 2. Establishment of early diagnostic technique. 3. Clarification of mechanisms of neuropathy. 4. Analysis of in vivo growth mechanisms of Mycobacterium leprae. 5. Molecular epidemiology of leprosy. 6. Searching for new anti leprosy drugs. 7. Developing vaccine. 8. In vitro cultivation. Other subjects as follows was proposed as prospective studies. 1. Mechanisms of relapse. 2. Establishing diagnostic tool of reaction and preventive measures. 3. Clarification of immunological mechanisms of anergy in LL case. The possibility of future collaboration between Korea and Japan to solve remaining problems in the clinical field was discussed and a course of action for collaboration was deliberated.</p>  a1342-3681