02112nas a2200349   4500000000100000008004100001260001600042653001500058653001000073653000900083653002200092653001000114653002100124653001100145653001100156653001200167653000900179653001600188653002600204653001600230100001900246700002000265700001600285700001800301700001400319245005400333856006900387300000600456490000700462520127900469022001401748       2012                            d  c2012 Sep 1510aAdolescent10aAdult10aAged10aAged, 80 and over10aChild10aChild, Preschool10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aRetrospective Studies10aYoung Adult1 aShivaswamy K N1 aShyamprasad A L1 aSumathy T K1 aRanganathan C1 aAgarwal V00aClinico histopathological correlation in leprosy.  uhttp://dermatology.cdlib.org/1809/01_rvw/2_11-00056/article.html  a20 v183 a<p><b>INTRODUCTION: </b>Leprosy is a chronic infectious disease caused by M. leprae, which presents in different clinico-pathological forms, depending upon the immune status of the host. Clinical classification gives recognition only to gross appearances of the lesions, whereas the parameters used for the histopathological classification are well defined, precise, and also take into account the immunological features.</p><p><b>RESULTS: </b>Of the 182 suspected cases of leprosy which were biopsied, the clinical diagnosis was TT in 32 (17.5%), BT in 70 (38.4%), BB in 5(2.7%), BL in 24 (13.1%), LL in 23 (12.6%), and indeterminate in 28 (15.3%) cases. Of the 182 cases, which were biopsied, only 136 (74.7%) showed histological features consistent with any one type of leprosy. The overall clinicohistological correlation was 74.7 percent. A comparison of the histopathological pattern with that of clinical pattern revealed that the maximum correlation was seen with LL (84.2%), followed by BL (73.3%), BT (64.1%), TT (56%), BB, and IL (50%).</p><p><b>CONCLUSION: </b>Because there is some degree of overlap in different types of leprosy, especially the unstable forms, the correlation can be made more accurate by combining clinical and histopathological features.</p>  a1087-2108