01843nas a2200313   4500000000100000008004100001260001300042653002000055653003700075653001300112653002600125653001100151653001200162653002500174653001700199653002600216653000900242653002600251100001100277700001100288700001100299700001100310700001500321245008300336300001000419490000700429520107900436022001401515       2012                            d  c2012 Sep10aContact Tracing10aDisease Transmission, Infectious10agenotype10aGenotyping Techniques10aHumans10aleprosy10aMycobacterium leprae10aNasal Mucosa10aPolymorphism, Genetic10aSkin10aTrinucleotide Repeats1 aAye KS1 aOo YTN1 aKyaw K1 aWin AA1 aMatsuoka M00aGenotyping of Mycobacterium leprae in Myanmar and possible transmission modes.  a191-80 v813 a<p>The polymorphism of TTC repeats in Mycobacterium leprae was examined using bacilli from slit skin samples of leprosy patients attending at Central Special Skin Clinic, Yangon General Hospital and nasal swabs of their contacts to elucidate the possible mode of leprosy transmission. It was found that bacilli with different TTC genotypes were distributed among same household contacts and also harbored bacilli in patients were different TTC genotype from that harbored on the nasal mucus of the healthy contacts. Genotypes of TTC repeats were found to differ between husband under treatment and his wife and also mother under treatment and her sons living in same house. This study revealed that TTC genotype of bacilli harbored by household contacts was different with the TTC genotype by index cases. These results indicate that the family members get transmission from outside the dwellings rather than from commonly supposed their MB index cases. There might have been some infectious sources to which the populace had been commonly exposed outside the dwellings.</p>  a1342-3681