01951nas a2200313   4500000000100000008004100001260003300042653001800075653002300093653004100116653003800157653001800195653001100213653001300224653001200237653002500249653003000274653003600304653002800340100002400368700001900392700001300411700001600424245005900440300001000499490000800509520110600517022001401623       2012                            d  c2012 SepbElsevier IncaS.l.10aBase Sequence10aDatabases, Genetic10aDrug Resistance, Multiple, Bacterial10aGenetic Predisposition to Disease10aGenome, Human10aHumans10aInternet10aleprosy10aMycobacterium leprae10aNucleic Acid Conformation10aPolymorphism, Single Nucleotide10aUser-Computer Interface1 aGeorge Priya Doss C1 aNagasundaram N1 aSrajan J1 aChiranjib C00aLSHGD: a database for human leprosy susceptible genes.  a162-60 v1003 a<p>Studies aiming to explore the involvement of host genetic factors to determine susceptibility to develop disease and individual's response to the infection with Mycobacterium leprae have increased in recent years. To address this issue, we have developed a Leprosy Susceptible Human Gene Database (LSHGD) to integrate leprosy and human associated 45 genes by profound literature search. This will serve as a user-friendly and interactive platform to understand the involvement of human polymorphisms (SNPs) in leprosy, independent genetic control over both susceptibility to leprosy and its association with multi-drug resistance of M. leprae. As the first human genetic database in leprosy it aims to provide information about the associated genes, corresponding protein sequences, available three dimensional structures and polymorphism related to leprosy. In conclusion, this will serve as a multifunctional valuable tool and convenient information platform which is freely available at http://www.vit.ac.in/leprosy/leprosy.htm and enables the user to retrieve information of their interest.</p>  a1089-8646