01438nas a2200205   4500000000100000008004100001260001600042653003100058653001100089653001200100653001100112653001800123100001200141700001800153245008300171300001000254490000700264520094700271022001401218       2001                            d  c2001 Mar 1510aEmigration and Immigration10aHumans10aleprosy10aTravel10aUnited States1 aOoi W W1 aMoschella S L00aUpdate on leprosy in immigrants in the United States: status in the year 2000.  a930-70 v323 a<p>The World Health Organization established a goal in 1991 of "elimination of leprosy as a public health problem by the year 2000." Although prevalence rates of leprosy have decreased in many geographic areas, it is clear that in some countries where leprosy is endemic, such as Brazil and India, this goal will not be reached. Leprosy is rare in the United States, but 85% of detected cases are in immigrants in whom the disease may mimic many common dermatologic and neurological entities, leading to delay of diagnosis. The statuses of polymerase chain reaction analysis, serological testing, and vaccines are reviewed. Effective multidrug therapy and prevention of permanent damage to nerves by early recognition and treatment will help prevent residual disabilities. This update reviews what is known about the pathophysiology and treatment of leprosy. Increased awareness will lead to earlier recognition, diagnosis, and treatment.</p>  a1058-4838