01676nas a2200301   4500000000100000008004100001260001300042653001100055653002500066653002100091653001900112653001200131653002600143653003400169653001700203100001300220700002200233700001600255700001500271700001600286245022200302856007200524300001100596490000700607050001600614520073000630022001401360       2001                            d  c2001 May10aHumans10aImmunohistochemistry10aInterferon-gamma10aInterleukin-1210aleprosy10aNitric Oxide Synthase10aNitric Oxide Synthase Type II10aPrednisolone1 aLittle D1 aKhanolkar-Young S1 aCoulthart A1 aSuneetha S1 aLockwood DN00aImmunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reactions before and during prednisolone treatment.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC98301/pdf/ii003413.pdf  a3413-70 v69  aLITTLE 20013 a<p>The effects of prednisolone treatment on the cellularity and cytokine (gamma interferon, interleukin-12, and inducible nitric oxide synthase) profiles of leprosy skin type 1 (reversal) reactions were studied using immunohistochemistry. Skin biopsies were taken from 15 patients with leprosy type 1 (reversal) reactions at days 0, 7, 28, and 180 after the start of steroid treatment. Prednisolone treatment had little effect at day 7, but by day 28 significant decreases were found in cytokine levels. Some patients maintained cytokine production at days 28 and 180. These results illustrate the strong Th1 profile of type 1 reactional lesions, the slow response to steroid therapy, and continuing activity at 180 days.</p>  a0019-9567