01571nas a2200373   4500000000100000008004100001260004000042653001000082653001400092653001400106653001100120653001100131653001200142653000900154653001600163653002500179653000900204653003600213100001700249700001600266700001500282700001600297700001900313700001300332700001700345700001400362700001500376700001500391245018100406300001200587490000700599520057700606022001401183       2012                            d  c2012 AugbElsevieraParis; New York10aAdult10aApoptosis10aCaspase 310aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae10aSkin10aTransforming Growth Factor beta1 aQuaresma JAS1 aAlmeida FAC1 aAarão TLS1 aSoares LPMA1 aNunes Magno IM1 aFuzii HT1 aLibonati RMF1 aXavier MB1 aPagliari C1 aDuarte MIS00aTransforming growth factor β and apoptosis in leprosy skin lesions: possible relationship with the control of the tissue immune response in the Mycobacterium leprae infection.  a696-7010 v143 a<p>The course of leprosy depends of the host immune response which ranges from the lepromatous pole (LL) to the tuberculoid pole (TT). A comparative study was conducted in 60 patients with the LL and TT. The results showed a mean expression of TGF-β of 339 ± 99.4 cells/field for TT and of 519.2 ± 68.2 cells/field for LL. Frequency of apoptosis was 6.3 ± 1.8 in TT and 14.0 ± 6.1 in LL. A correlation (p = 0.0251) between TGF-β and caspase-3 in the LL was found. This finding indicates a role of TGF-β and apoptosis in the immune response in leprosy.</p>  a1769-714X