01576nas a2200385   4500000000100000008004100001260001600042653003700058653001800095653001100113653003100124653003800155653001300193653001100206653001200217653003500229653003600264653002400300653001200324100001100336700001400347700001300361700001500374700001200389700001300401700001000414700001200424700001300436700001200449245009900461300001100560490000800571520059700579022001401176       2012                            d  c2012 Dec 0110aAsian Continental Ancestry Group10aCrohn Disease10aFamily10aGene Expression Regulation10aGenetic Predisposition to Disease10agenotype10aHumans10aleprosy10aNod2 Signaling Adaptor Protein10aPolymorphism, Single Nucleotide10aSignal Transduction10aVietnam1 aAbel L1 aAlcaïs A1 aSchurr E1 aVan Thuc N1 aThai VH1 aHuong NT1 aBa NN1 aAlter A1 aOrlova M1 aGrant A00aCrohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.  a1763-70 v2063 a<p>A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.</p>  a1537-6613