01773nas a2200349   4500000000100000008004100001260004700042653002800089653001700117653001100134653002300145653001200168653000900180653001600189653002300205653001600228653001600244653002200260653002200282653001300304100001600317700001500333700001500348700001500363700001300378700001600391245014700407300001000554490000700564520083800571022001401409       2012                            d  c2012 AugbBlackwell Publishing LtdaLondon10aAdrenal Cortex Hormones10aCyclosporine10aHumans10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aPulmonary Embolism10aRadiography10aThalidomide10aTreatment Outcome10aVenous Thrombosis10aWarfarin1 aYamaguchi S1 aYamamoto Y1 aHosokawa A1 aHagiwara K1 aUezato H1 aTakahashi K00aDeep venous thrombosis and pulmonary embolism secondary to co-administration of thalidomide and oral corticosteroid in a patient with leprosy.  a711-40 v393 a<p>A 58-year-old Japanese man with a 2-year history of multidrug therapy for borderline lepromatous leprosy presented with skin lesions suggestive of erythema nodosum leprosum (ENL) and was treated with an oral corticosteroid. As attempts to taper the oral corticosteroid resulted in the appearance of new lesions, thalidomide was added along with cyclosporin. Two months after the introduction of thalidomide, deep venous thrombosis (DVT) occurred in both legs and anticoagulant therapy was started without cessation of thalidomide. Pulmonary embolism developed 1 month after the appearance of DVT, and these thromboembolic events were believed to be due to thalidomide. This case highlights the need for vigilance against venous thromboembolism when corticosteroid and thalidomide are co-administrated for the treatment of ENL.</p>  a1346-8138