01371nas a2200289   4500000000100000008004100001260001300042653001200055653001200067653000900079653001100088653001200099653000900111653003200120653002500152653000900177100001500186700001500201700001500216700001900231700001100250245008200261300001000343490000600353520070800359022001401067       1975                            d  c1975 Nov10aAnimals10aDapsone10aDiet10aFemale10aleprosy10aMale10aMicrobial Sensitivity Tests10aMycobacterium leprae10aRats1 aPeters J H1 aGordon G R1 aMurray J F1 aFieldsteel A H1 aLevy L00aMinimal inhibitory concentration of dapsone for Mycobacterium leprae in rats.  a551-70 v83 a<p>To define the minimal inhibitory concentration (MIC) of dapsone (DDS) for Mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of DDS in uninfected male and female Lewis rats. This knowledge was applied to the design of experiments using rats inoculated in the footpads with M. leprae. The MIC for DDS in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of DDS/ml of plasma, even though the sexes exhibited markedly different concentrations of DDS when receiving the same dietary level of DDS. These values for the MIC of DDS for M. leprae in rats are nearly identical to the previously determined MIC of DDS for M. leprae in mice.</p>  a0066-4804