01144nas a2200181   4500000000100000008004100001260001600042653001200058100001700070700001700087700001700104700001700121700001500138700001400153245013400167520064700301022001400948       2012                            d  c2012 Jun 2310aleprosy1 aScheinberg M1 aRibeiro SL E1 aPereira HL A1 aMangueira CL1 aFerreira C1 aRosseto E00aThe development of arthritis and antinuclear antibodies correlate with serum 25-hydroxyvitamin D levels in patients with leprosy.3 aLeprosy, a chronic granulomatous infection, presents with cutaneous and neurological manifestations. Musculoskeletal involvement, though the third most common manifestation, is underdiagnosed.1 ,2 In its natural history, other immune manifestations besides articular manifestations may be present, such as the presence of autoantibodies.3 ,4 There is evidence that vitamin D influences the activity of immune-mediated diseases, particularly autoimmune diseases.5 ,6 Amazon is a state in the northern part of Brazil where the disease is endemic. It has a high level of sunshine, so a low prevalence of vitamin D insufficiency would be expected  a1468-2060