02408nas a2200457   4500000000100000008004100001260005100042653003700093653002300130653003100153653001100184653001100195653002000206653003800226653003400264653001100298653001200309653001400321653000900335653001300344653003600357100001100393700001000404700001000414700001100424700000900435700000900444700000900453700001100462700001000473700001100483700001200494700001000506700001200516245006000528856006900588300001100657490000600668520126200674022001401936       2012                            d  c2012bPublic Library of ScienceaSan Francisco10aAsian Continental Ancestry Group10aChromosomes, Human10aChromosomes, Human, Pair 210aFamily10aFemale10aGenetic Linkage10aGenetic Predisposition to Disease10aGenome-Wide Association Study10aHumans10aleprosy10aLod Score10aMale10aPedigree10aPolymorphism, Single Nucleotide1 aYang Q1 aLiu H1 aLow H1 aWang H1 aYu Y1 aFu X1 aYu G1 aChen M1 aYan X1 aChen S1 aHuang W1 aLiu J1 aZhang F00aChromosome 2p14 is linked to susceptibility to leprosy.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253103/?tool=pubmed  ae297470 v73 a<p><b>BACKGROUND: </b>A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established.</p><p><b>METHODOLOGY: </b>A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1.</p><p><b>PRINCIPAL FINDINGS: </b>Genome-wide significant evidence for linkage was identified on chromosome 2p14 with a heterogeneity logarithm of odds (HLOD) score of 3.51 (rs1106577) under a recessive model of inheritance, while suggestive evidence was identified on chr.4q22 (HLOD 2.92, rs1349350, dominant model), chr. 8q24 (HLOD 2.74, rs1618523, recessive model) and chr.16q24 (HLOD 1.93, rs276990 dominant model). Our study also provided moderate evidence for a linkage locus on chromosome 6q24-26 by non-parametric linkage analysis (rs6570858, LOD 1.54, p = 0.004), overlapping a previously reported linkage region on chromosome 6q25-26.</p><p><b>CONCLUSION: </b>A genome-wide linkage analysis has identified a new linkage locus on chromosome 2p14 for leprosy in Pedigrees from China.</p>  a1932-6203