01572nas a2200409   4500000000100000008004100001260006100042653002300103653001200126653001100138653001000149653002300159653001200182653002700194653001300221653002500234653001600259653001300275100000900288700001500297700001300312700001500325700001300340700001700353700001600370700001400386700001000400700001100410700001500421700001400436700001200450245009600462300001100558490000700569520057200576022001401148       2011                            d  c2011 Novb American Society for MicrobiologyaWashington10aBacterial Proteins10aDapsone10aHumans10aIndia10aLeprostatic Agents10aleprosy10aMolecular Epidemiology10aMutation10aMycobacterium leprae10aPhilippines10aRifampin1 aLi W1 aSakamuri R1 aLyons DE1 aOrcullo FM1 aShinde V1 aDela Pena EL1 aMaghanoy AA1 aMallari I1 aTan E1 aNath I1 aBrennan PJ1 aBalagon M1 aVissa V00aTransmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.  a5384-70 v553 a<p>Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.</p>  a1098-6596