02306nas a2200493 4500000000100000008004100001260001300042653001500055653001000070653001600080653000900096653002200105653001100127653002500138653001000163653002100173653001100194653001300205653001500218653001100233653002100244653001200265653000900277653002700286653001600313653002500329653001500354653003600369653001600405100002000421700001600441700001300457700001700470700002100487700001900508700001700527700001200544700001900556245010700575300001100682490000700693520109800700022001401798 2011 d c2011 Aug 10 aAdolescent 10 aAdult 10 aAge Factors 10 aAged 10 aAged, 80 and over 10 aBrazil 10 aCase-Control Studies 10 aChild 10 aChild, Preschool 10 aFemale 10 agenotype 10 aHaplotypes 10 aHumans 10 aImmunity, Innate 10 aleprosy 10 aMale 10 aMannose-Binding Lectin 10 aMiddle Aged 10 aMycobacterium leprae 10 aOdds Ratio 10 aPolymorphism, Single Nucleotide 10 aYoung Adult 1 aVasconcelos LRS 1 aFonseca JPL 1 aCarmo RF 1 aMendonça TF 1 aAlves Pereira VR 1 aLucena-Silva N 1 aPereira LMMB 1 aMoura P 1 aCavalcanti MSM 00 aMannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes. ae551-7 0 v15 3 aBACKGROUND: Mannose-binding lectin (MBL) activates the complement system promoting opsonophagocytosis, which could represent an advantage for Mycobacterium leprae, an intracellular pathogen. Therefore, a single nucleotide polymorphism (SNP) in the MBL2 gene associated with low levels of MBL could confer protection against the development of leprosy disease.
METHODS: In this study, we investigated SNPs of the MBL2 gene and MBL levels in 228 Brazilian leprosy patients and 232 controls.
RESULTS: There were no differences in the frequencies of variant genotypes and haplotypes of MBL2 between patients and controls, or between the different clinical forms of leprosy. In the group of patients with a genotype for high expression of MBL2, those aged>40 years had decreased MBL levels compared to patients aged ≤ 40 years (p = 0.037).
CONCLUSION: Our results demonstrate that age could influence the phenotype of MBL2, but no evidence was found for an association of MBL2 polymorphism with susceptibility to leprosy or its clinical forms.
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