02368nas a2200385   4500000000100000008004100001260001300042653001500055653001000070653002000080653001600100653001200116653003000128653001100158653001100169653001000180653002300190653001200213653000900225653002400234653001300258653001700271100001200288700001000300700001000310700001300320700001400333245018500347856005100532300001000583490000700593050001500600520135300615022001401968       2011                            d  c2011 Mar10aAdolescent10aAdult10aBody Mass Index10aClofazimine10aDapsone10aDrug Therapy, Combination10aFemale10aHumans10aIndia10aLeprostatic Agents10aleprosy10aMale10aProspective Studies10aRifampin10aRisk Factors1 aSingh H1 aNel B1 aDey V1 aTiwari P1 aDulhani N00aAdverse effects of multi-drug therapy in leprosy, a two years' experience (2006-2008) in tertiary health care centre in the tribal region of Chhattisgarh State (Bastar, Jagdalpur).  uhttps://leprosyreview.org/article/82/1/01-7024  a17-240 v82  aSINGH 20113 a<p><b>OBJECTIVE: </b>To assess the adverse effects of multi drug therapy (MDT) in leprosy patients.</p><p><b>METHODS: </b>A prospective and descriptive study carried out in Department of Dermatology, Government Medical College, Jagdalpur. The adverse effects were recorded on the personal record of every individual patient, filled during the course of treatment.</p><p><b>RESULTS: </b>176 patient's records were analysed, looking for adverse effects. Among the 176 patients, 79 had adverse effects due to one or more components of MDT, 73 had adverse effects due to dapsone, eight due to rifampicin and 16 due to clofazimine. Mean (+/- SD) duration for the development of adverse effects from the start of therapy was 1.99 (+/- 0.69) months for dapsone, 36 (+/- 0.68) months for rifampicin and 7.13 (+/- 0.79) months for clofazimine. There was a significant (P < 0.05) correlation between adverse effects and low Body Mass Index (BMI). The suspected drug was stopped and an alternative regime started in nine patients; six had dapsone stopped, two had rifampicin stopped and one had clofazimine stopped.</p><p><b>CONCLUSION: </b>Adverse effects attributed to MDT are comparable to previous studies and we found that ADR due to Dapsone was very high but most of the ADR were managed by supportive treatment without replacing the suspected drug.</p>  a0305-7518