01784nas a2200409   4500000000100000008004100001260001300042653001000055653001200065653001100077653001100088653001900099653003800118653004100156653002000197653002000217653002000237653001100257653001200268653000900280653001600289653001600305100002400321700001800345700002500363700002100388700001300409700001300422700002200435700001400457700001600471245010900487300001000596490000700606520074700613022001401360       2011                            d  c2011 Jun10aAdult10aAlleles10aBrazil10aFemale10aGene Frequency10aGenetic Predisposition to Disease10aHistocompatibility Antigens Class II10aHLA-DQ Antigens10aHLA-DR Antigens10aHLA-DRB1 Chains10aHumans10aleprosy10aMale10aMiddle Aged10aYoung Adult1 aLavado-Valenzuela R1 aJosé Bravo M1 aJunqueira-Kipnis A P1 aRamos de Souza M1 aMoreno C1 aAlonso A1 aLiberman-Kipnis T1 aSilva W D1 aCaballero A00aDistribution of the HLA class II frequency alleles in patients with leprosy from the mid-west of Brazil.  a255-80 v383 a<p>In an attempt to clarify the issue of genetic predisposition to leprosy, we examined the distribution of class II human leucocyte antigen variants (DR and DQ) in 70 patients from around the city of Goiânia, Brazil. Only two of the patients presented the tuberculoid form of the disease, whereas 17 fell into the lepromatous category; 51 were intermediate. The allele frequencies found were compared with those in a group of 77 healthy controls. We found an increased frequency of the HLA-DRB1*11 allele in patients with lepromatous leprosy compared with healthy controls (P=0.0132; RR=4.130, 95% Cl: 1.338 to 12.747). These results suggest that the DRB1*11 allele could be related with susceptibility to lepromatous leprosy in Brazil.</p>  a1744-313X