01310nas a2200193   4500000000100000008004100001653002100042653003000063653001300093653001200106100001700118700001200135700002100147245005300168856014200221300001200363490000700375520073400382       2011                            d10aAutoinflammatory10aErythema Nodosum Leprosum10aReaction10aleprosy1 aQuandelacy T1 aHoltz M1 aFranco-Paredes C00aAre leprosy reactions autoinflammatory diseases?  uhttp://www.nietoeditores.com.mx/download/bol_med_HIM/MARZO-ABRIL%202011/BOL%20Med%20Hosp%20espa%C3%B1ol/Bol%20Med%20Hosp%202.10%20ARE.pdf  a127-1290 v683 aThere are two types of leprosy reactions: reversal reactions or type 1 and erythema nodosum leprosum or type 2. Deformity and disability
associated with leprosy are frequently the result of uncontrolled or untreated reactions. Although there is current availability of glucocorticoids
as the mainstay of therapy, much needs to be learned about the etiology, risk factors, and pathogenesis of leprosy reactions. There
is some evidence that leprosy reactions may represent, particularly, erythema nodosum leprosum autoinflammatory disease due to the
aberrant activation of the innate immune system. The role for herpesviruses influencing autophagy in macrophages needs to be evaluated
in the pathogenesis of leprosy reactions.