01365nas a2200241   4500000000100000008004100001260001300042653002600055653004400081653001200125653002400137653001100161653001200172653001800184653001800202100001400220700001300234245003100247300001600278490000700294520080800301022001401109       2001                            d  c2001 Jan10aAnti-Infective Agents10aAnti-Inflammatory Agents, Non-Steroidal10aDapsone10aDermatologic Agents10aHumans10aleprosy10aSkin Diseases10aSulfapyridine1 aPaniker U1 aLevine N00aDapsone and sulfapyridine.  a79-86, viii0 v193 a<p>Dapsone and sulfapyridine are structurally related compounds with anti-microbial and anti-inflammatory effects. Dapsone remains the most important drug for leprosy and is useful in the prophylaxis of Pneumocystis pneumonia in patients with HIV disease. The medical treatment of choice for dermatitis herpetiformis is dapsone; and sulfapyridine also can be used for those patients who are intolerant of dapsone. Other neutrophilic disorders also may respond to these drugs. Toxic side effects of both dapsone and sulfapyridine are mediated through the hydroxylamine metabolite. These include hemolysis, methemoglobinemia, and agranulocytosis. Careful monitoring for possible adverse reactions includes frequently performing complete blood counts and regular blood chemistry profile determinations.</p>  a0733-8635