01223nas a2200217   4500000000100000008004100001260001300042653001100055653002400066653000900090653001800099653002400117100001800141700001400159700001500173245003400188300001300222490000700235520074900242022001400991       2011                            d  c2011 Sep10aHumans10aSignal Transduction10aSkin10aSkin Diseases10aToll-Like Receptors1 aErmertcan A T1 aOztürk F1 aGündüz K00aToll-like receptors and skin.  a997-10060 v253 a<p>Toll-like receptors are important pattern recognition receptors which have key roles in both innate and adaptive immune responses. They are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, Toll-like receptors have also been implicated in the pathogenesis of several skin diseases such as skin infections, psoriasis, acne vulgaris, lichen planus, Behçet's disease, leprosy, syphilis, Lyme disease, atopic dermatitis and allergic contact dermatitis, mycosis fungoides, non-melanoma skin cancers and melanoma. In this manuscript, the structure and functions of Toll-like receptors in immune responses, their impact on skin diseases and recent advances on therapeutic usage have been reviewed.</p>  a1468-3083