00866nas a2200217 4500000000100000008004100001260001300042653001200055653002400067653001600091653001100107653001200118653002500130653001800155100001400173245005800187300000900245490000600254520037400260022001400634 2001 d c2001 Feb10aAnimals10aAntigens, Bacterial10aGlycolipids10aHumans10aleprosy10aMycobacterium leprae10aSchwann Cells1 aYoung D B00aLeprosy lipid provides the key to Schwann cell entry. a52-40 v93 a

A recent study has demonstrated that the species-specific phenolic glycolipid of Mycobacterium leprae triggers uptake into Schwann cells by interaction with laminin-2 and the alpha-dystroglycan receptor. This finding emphasizes the importance of lipids in the biology of mycobacterial infection and suggests possible strategies to combat nerve damage in leprosy.

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