02407nas a2200517   4500000000100000008004100001260001600042653001500058653001000073653000900083653001000092653002100102653001900123653003800142653001300180653004000193653001100233653001000244653001100254653001200265653001600277653003600293653001200329653001600341100001200357700001300369700001200382700001300394700001500407700001300422700001000435700001200445700001000457700001700467700001100484700001200495700001400507700001300521245014000534856007100674300001200745490000800757050001500765520109500780022001401875       2011                            d  c2011 May 0110aAdolescent10aAdult10aAged10aChild10aChild, Preschool10aGene Frequency10aGenetic Predisposition to Disease10agenotype10aHistocompatibility Antigens Class I10aHumans10aIndia10aInfant10aleprosy10aMiddle Aged10aPolymorphism, Single Nucleotide10aVietnam10aYoung Adult1 aAlter A1 aHuong NT1 aSingh M1 aOrlova M1 aVan Thuc N1 aKatoch K1 aGao X1 aThai VH1 aBa NN1 aCarrington M1 aAbel L1 aMehra N1 aAlcaïs A1 aSchurr E00aHuman leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069725/pdf/jir024.pdf  a1274-810 v203  aALTER 20113 a<p>Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy families replicated the association of 12 SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 × 10⁻⁹)-rs2394885 and rs2922997 (marginal multivariate P = 2.1 × 10⁻⁷ and P = .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the Vietnamese population. The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis.</p>  a1537-6613