01631nas a2200349   4500000000100000008004100001260001300042653001000055653001600065653001100081653003800092653001100130653002300141653001200164653000900176653002600185653003000211653002600241653001300267100001500280700001300295700001700308700001600325700001600341700001900357245012200376856005600498300001000554490000700564520069600571022001401267       2011                            d  c2011 Apr10aChild10aClofazimine10aFamily10aGenetic Predisposition to Disease10aHumans10aLeprostatic Agents10aleprosy10aMale10aPolymorphism, Genetic10aPromoter Regions, Genetic10aReceptors, Interferon10aRifampin1 aVelayati A1 aFarnia P1 aKhalizadeh S1 aFarahbod AM1 aHasanzadh M1 aSheikolslam MF00aInterferon-gamma receptor-1 gene promoter polymorphisms and susceptibility to leprosy in children of a single family.  uhttp://www.ajtmh.org/content/84/4/627.full.pdf+html  a627-90 v843 a<p>The autosomal recessive disorder, because of a single mutation in interferon-γ receptor-1(IFNGR1) at position -56, was found to be associated with susceptibility to leprosy in children of the same family. The existence of such heterozygous carriers might explain the crucial role of IFNGR1 in the host defense against intracellular pathogens such as Mycobacterium leprae. The single nucleotide polymorphisms (SNPs) in major candidate genes, i.e., natural resistance-associated macrophage protein 1 (NRAMP1), vitamin D receptor (VDR), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), interleukin-12-receptor 1 (IL-12R1), were not found to be associated with this disease.</p>  a1476-1645