02364nas a2200409   4500000000100000008004100001260001700042653001500059653001000074653000900084653001000093653001900103653003000122653001100152653002200163653001100185653001400196653001000210653002300220653002800243653000900271653001600280653002300296653001500319653001700334653001600351100001300367700001400380700001600394700001700410245013600427856009300563300001000656490000700666520126700673022001401940       2010                            d  c2010 Oct-Dec10aAdolescent10aAdult10aAged10aChild10aCohort Studies10aDrug Therapy, Combination10aFemale10aFollow-Up Studies10aHumans10aIncidence10aIndia10aLeprostatic Agents10aLeprosy, Multibacillary10aMale10aMiddle Aged10aOcular Hypotension10aPrevalence10aRisk Factors10aYoung Adult1 aDaniel E1 aRao P S S1 affytche T J1 aCourtright P00aOcular hypotension and hypotony in multibacillary leprosy patients; at diagnosis, during and after completion of multidrug therapy.  uhttp://www.ijl.org.in/archives/oct-dec-2010/Art1(Ebenezer%20Daniel%20et%20al)181-188.pdf  a181-80 v823 a<p>The prevalence and incidence of ocular hypotony (IOP < 7 mm Hg) and factors associated with them were determined in a Leprosy Referral Centre at Tamilnadu, India. Applanation intraocular pressures were measured every six months in a cohort of newly diagnosed multibacillary (MB) leprosy patients who were followed-up during the two year period of multidrug therapy (MDT) and for five years thereafter. Transient hypotony was present in two patients at the time of diagnosis, in 3 patients during MDT and in 9 patients after MDT with a cumulative prevalence of 4.65%. Transient ocular hypotension was present in 24 patients (8%) at disease diagnosis. 25 patients developed hypotension during MDT that was associated with trichiasis (HR 8.83 95% CI 2.06, 37.78 p = 0.003) and flare or/and cells (HR 4.60 95% CI 1.08, 19.64 p = 0.039). 29 patients developed ocular hypotension after MDT that was associated with punctate keratitis and uveal involvement. In general, MB leprosy patients with hypotension had a mean IOP of 12.60 mm Hg which differed significantly (p < 0.0001) from the mean IOP of 14.9 mm Hg in those who did not have hypotension. Transient hypotension and hypotony in MB leprosy patients are associated with signs of intraocular inflammation.</p>  a0254-9395