02521nas a2200397   4500000000100000008004100001260001700042653001500059653001000074653002500084653002700109653001100136653001100147653002800158653002500186653002500211653000900236653001600245653001400261653002400275653001700299653002100316653001600337100001700353700001600370700001500386700001500401700001400416245008300430856010600513300001100619490000700630050003600637520143600673022001402109       2010                            d  c2010 Nov-Dec10aAdolescent10aAdult10aDinitrochlorobenzene10aDisease Susceptibility10aFemale10aHumans10aIndicators and Reagents10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMale10aMiddle Aged10aPhenotype10aRadiation Tolerance10aRisk Factors10aUltraviolet Rays10aYoung Adult1 aRodrigues MM1 aXimenes RAA1 aDantas MMS1 aBatista TD1 aFreire AL00aUVB susceptibility as a risk factor to the development of lepromatous leprosy.  uhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962010000600009&lng=en&nrm=iso&tlng=en  a839-420 v85  aRODRIGUES 2010/ RODRIGUES 2010a3 a<p><b>BACKGROUNDS: </b>Ultraviolet radiation B (UVRB) is the most important environmental factor capable of altering the immune function of human skin.</p><p><b>OBJECTIVE: </b>To evaluate the association of the phenotypes of susceptibility or resistance to ultraviolet radiation B (UVRB) and the polar forms of leprosy.</p><p><b>MATERIAL AND METHODS: </b>We evaluated 38 patients with lepromatous leprosy (LL) and 87 patients with tuberculoid (TT) leprosy, according to the classification by Ridley and Jopling (1966). All the patients were submitted to a test to determine the phenotypes of susceptibility or resistance to UVRB through the application of a 2% dinitrochlorobenzene (DNCB) disc to a previously irradiated area with twice the minimal erythema dose (MED). After 21 days, a similar disc soaked in 0.05% DNCB was applied to the scapular area (unexposed to UVRB) to check for sensitiveness, with reading of the results after 48 hours. The patients that showed a positive reaction to DNCB were considered resistant (UVB-R) and those who did not show any reaction were considered susceptible (UVB-S).</p><p><b>RESULTS: </b>The frequency of UVB-S individuals was 63.2% (24 patients) in the LL group and 34.4% (30 patients) in the TT group (OR=3.26; IC=1.36 - 7.87; x(2)=7.73; p=0.005).</p><p><b>CONCLUSION: </b>Our results suggest that UVB-susceptibility is a risk factor to the development of lepromatous leprosy (LL).</p>  a1806-4841