02281nas a2200493   4500000000100000008004100001260001300042653001100055653002300066653003200089653003100121653003100152653001100183653002000194653002000214653003800234653002000272653001800292653001100310653001000321653001200331653000900343653001700352100001500369700001700384700001400401700001400415700001300429700001600442700001600458700001300474700001900487700001300506700001200519700001500531700001800546245008700564856006200651300000900713490000600722050001600728520102900744022001401773       2004                            d  c2004 Jan10aBrazil10aChromosome Mapping10aChromosomes, Human, Pair 1510aChromosomes, Human, Pair 410aChromosomes, Human, Pair 610aFemale10aGenetic Linkage10aGenetic Markers10aGenetic Predisposition to Disease10aGenetic Testing10aGenome, Human10aHumans10aIndia10aleprosy10aMale10aTuberculosis1 aMiller E N1 aJamieson S E1 aJoberty C1 aFakiola M1 aHudson D1 aPeacock C S1 aCordell H J1 aShaw M-A1 aLins-Lainson Z1 aShaw J J1 aRamos F1 aSilveira F1 aBlackwell J M00aGenome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians.  uhttp://www.nature.com/gene/journal/v5/n1/pdf/6364031a.pdf  a63-70 v5  aMILLER 20043 a<p>Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1, 405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric multipoint analysis detected 8 and 9 chromosomal regions respectively with provisional evidence (P<0.05) for linkage. At stage 2, 58 markers from positive regions were typed in a second set of 22 (176 individuals) tuberculosis families, with 22 additional markers typed in all families; 42 positive markers in 50 (192 individuals) new leprosy families, and 30 additional markers in all families. Three regions (10q26.13, 11q12.3, 20p12.1) retained suggestive evidence (peak LOD scores 1.31, 1.85, 1.78; P=0.007, 0.0018, 0.0021) for linkage to tuberculosis, 3 regions (6p21.32, 17q22, 20p13) to leprosy (HLA-DQA, 3.23, P=5.8 x 10(-5); D17S1868, 2.38, P=0.0005; D20S889, 1.51, P=0.004). The peak at D20S889 for leprosy is 3.5 Mb distal to that reported at D20S115 for leprosy in India. (151 words).</p>  a1466-4879