01303nas a2200313   4500000000100000008004100001260001300042653001000055653000900065653001200074653001500086653001100101653002300112653001300135653001200148653001500160653001600175653000900191653001600200653002500216100001500241700001400256700001500270245005800285300001000343490000700353520061500360022001400975       1975                            d  c1975 Sep10aAdult10aAged10aAnimals10aArmadillos10aHumans10aImmunity, Cellular10aLepromin10aleprosy10aLevamisole10aLymphocytes10aMice10aMiddle Aged10aMycobacterium leprae1 aMeyers W M1 aKvernes S1 aStaple E M00aFailure of levamisole to alter the lepromin reaction.  a857-90 v243 a<p>In a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the Fernandez and Mitsuda reactions to lepromins of human and armadillo origin. We interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. Current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside in the lymphocyte and not the macrophage, or the respective related functions of these two cell forms.</p>  a0002-9637