01343nas a2200325   4500000000100000008004100001260001300042653001200055653001600067653002100083653003000104653002000134653002000154653003800174653001100212653002100223653001200244653002200256653000900278653002800287653003000315100001000345700001500355700001300370245003400383300001000417490001500427520056100442022001401003       2000                            d  c2000 Sep10aAnimals10aBCG Vaccine10aCarrier Proteins10aCation Transport Proteins10aGenetic Linkage10aGenetic Markers10aGenetic Predisposition to Disease10aHumans10aImmunity, Innate10aleprosy10aMembrane Proteins10aMice10aTuberculosis, Pulmonary10aUrinary Bladder Neoplasms1 aBuu N1 aSánchez F1 aSchurr E00aThe Bcg host-resistance gene.  aS81-50 v31 Suppl 33 a<p>In the mouse, resistance and susceptibility to intracellular growth of mycobacteria in macrophages is controlled by the Bcg (Nramp1) gene, which has been cloned and shown to encode a macrophage phagosomal membrane protein with a putative transporter function. In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with human responses to mycobacteria, including susceptibility to tuberculosis and leprosy, as well as BCG immunotherapy in bladder cancer.</p>  a1058-4838