01502nas a2200265   4500000000100000008004100001260001300042653001000055653002100065653001100086653001800097653002500115653000900140100001300149700001700162700001600179700001500195700001200210245009200222856004100314300001000355490000700365520085000372022001401222       2000                            d  c2000 Jun10aAdult10aErythema Nodosum10aHumans10aIridocyclitis10aLeprosy, lepromatous10aMale1 aDaniel E1 aEbenezer G J1 affytche T J1 aSigamani A1 aJob C K00aEpithelioid granuloma in the iris of a lepromatous leprosy patient; an unusual finding.  uhttp://ila.ilsl.br/pdfs/v68n2a05.pdf  a152-50 v683 a<p>This case report depicts a case of histopathologically confirmed polar lepromatous (LL) leprosy with a bacterial index of 4+. He experienced recurrent episodes of erythema nodosum leprosum (ENL) in the first 5 years after diagnosis. Skin smears became negative after 6 years of dapsone monotherapy and have remained negative since that time. At 23 years after diagnosis, the patient had developed cataracts and underwent intracapsular cataract extractions with broad-based iridectomies. In one of the iris specimens, histopathologic examination revealed a focal granuloma composed of epithelioid cells. Subsequently a lepromin skin test showed a positive Mitsuda reaction with a borderline tuberculoid histopathology. This clearly illustrates the immunological upgrading of a polar lepromatous patient, perceived first in the iris tissue.</p>  a0148-916X