02058nas a2200457 4500000000100000008004100001260001300042653001500055653001000070653000900080653002800089653002000117653001000137653002700147653002800174653002300202653001100225653002000236653001100256653001900267653002300286653001200309653000900321653002100330653001600351653003500367653002500402653001300427653001900440653001300459653001800472100001400490700001700504700001200521700001500533245008200548300001200630490001500642520092900657022001401586 2000 d c2000 Oct10aAdolescent10aAdult10aAged10aArthropathy, Neurogenic10aBone Resorption10aChild10aDiabetes Complications10aDiagnosis, Differential10aDiagnostic Imaging10aFemale10aFractures, Bone10aHumans10aJoint Diseases10aJoint Loose Bodies10aleprosy10aMale10aMeningomyelocele10aMiddle Aged10aPain Insensitivity, Congenital10aSpinal Cord Injuries10aSteroids10aSynovial Fluid10aSyphilis10aSyringomyelia1 aJones E A1 aManaster B J1 aMay D A1 aDisler D G00aNeuropathic osteoarthropathy: diagnostic dilemmas and differential diagnosis. aS279-930 v20 Spec No3 a

The purpose of this pictorial essay is to illustrate the radiologic spectrum of imaging findings of neuropathic osteoarthropathy. Typical findings include joint destruction, disorganization, and effusion with osseous debris. A variety of other imaging findings related to neuropathic osteoarthropathy such as resorption of the ends of tubular bones and neuropathic fracture are shown. The two prevailing theories for the pathophysiology of neuropathic bone and joint disease, the neurovascular and neurotraumatic theories, are briefly described. Examples of osteoarthropathy from diverse causes are presented including syringomyelia, spinal cord injury, meningomyelocele, diabetes mellitus, congenital insensitivity to pain, steroid injections, syphilis, leprosy, and others. The discussion focuses on key imaging features with emphasis on disease patterns and differential diagnosis, which vary by skeletal location.

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