01153nas a2200265   4500000000100000008004100001260001300042653001200055653001100067653001200078653002800090653000900118653001900127653002600146653003400172100001400206700001200220700001900232245009100251856007300342300001100415490000700426520044000433022001400873       2000                            d  c2000 Sep10aAnimals10aHumans10aleprosy10aMacrophages, Peritoneal10aMice10aMice, Knockout10aNitric Oxide Synthase10aNitric Oxide Synthase Type II1 aAdams L B1 aJob C K1 aKrahenbuhl J L00aRole of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC101819/pdf/ii005462.pdf  a5462-50 v683 a<p>The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.</p>  a0019-9567