02212nas a2200433   4500000000100000008004100001260000900042653001000051653000900061653003300070653001000103653003000113653003100143653001100174653001500185653003900200653001100239653001900250653001200269653000900281653000900290653003200299653001600331653001600347653002700363653002600390653002900416653003500445653002600480100002000506700001600526700001300542700001200555245013000567300001000697490000700707520105000714022001401764       1999                            d  c199910aAdult10aAged10aAnti-Infective Agents, Local10aChild10aCombined Modality Therapy10aDrug Resistance, Microbial10aFemale10aFoot Ulcer10aGram-Negative Bacterial Infections10aHumans10aImmobilization10aleprosy10aMale10aMali10aMicrobial Sensitivity Tests10aMiddle Aged10aPseudomonas10aPseudomonas Infections10aRetrospective Studies10aSkin Diseases, Bacterial10aStaphylococcal Skin Infections10aStaphylococcus aureus1 aTiendrebéogo A1 aCoulibaly I1 aSarr A M1 aSow S O00a[Nature and sensitivity of bacteria superinfecting plantar ulcers caused by leprosy at the Marchoux Institute, Bamako, Mali].  a153-90 v113 a<p>To determine potential usefulness of antimicrobial agents and to guide their prescription in the treatment of leprosy plantar ulcers, we conducted an in vitro study about germs' nature and sensitivity to antibiotics. We took samples of plantar ulcers secretion from 107 patients at Marchoux Institute. 92.5% of those ulcers were infected. These samples revealed 145 strains of micro-organisms among those, Staphylococcus aureus (70 strains) and genus Pseudomonas (41 strains) were the most frequent. These bacteria were resistant to several antibiotics currently used at Marchoux Institute (tetracycline, penicillin, cotrimoxazol and erythromicin). Antibiotics, efficient at 80% on tested strains, were expensive for patients. They cannot be recommended for the treatment of local infections. These results outline that the main treatment in plantar ulcers is based upon antiseptic solutions and keeping feet at rest. Antibiotherapy in case of extension of local infection would be based on the results of a previous study of sensitivity.</p>  a0001-5938