02351nas a2200313   4500000000100000008004100001260001300042653001000055653003200065653001800097653002000115653000900135653000900144653001100153653001200164653002400176653001600200653002200216100001300238700001100251700001400262700001400276700002000290245005000310300001100360490000700371520164500378022001402023       1976                            d  c1976 Jul10aAdult10aArterial Occlusive Diseases10aBlood Vessels10aBrachial Artery10aFoot10aHand10aHumans10aleprosy10aNutrition Disorders10aRadiography10aVascular Diseases1 aWahi P L1 aKaur S1 aVadwa M B1 aSodhi J S1 aChakravarti R N00aPeripheral arteriographic studies in leprosy.  a365-700 v273 a<p>There is a considerable controversy regarding the frequency and significance of vascular lesions in leprosy. Twenty-six cases of leprosy below the age of 40 years, without any local or systemic arterial disease and normal looking hands were subjected to brachial arteriography. One patient had posterior tibial arteriography also. The diagnosis of leprosy was confirmed by histology or bacteriological staining techniques. Biopsy material was studied from the involved areas and similar material was obtained from nine matched control subjects at autopsy. Skin thermometry and reflex vasodilatation was studied in eight cases. Arteriographic abnormalities such as occlusion, narrowing, tortuosity, dilatation, irregularity and incomplete filling were seen in more than two vessels in the hand in 50%, and in the digits in 75% of the cases. The ulnar artery was more frequently involved than the radial. Superficial and deep palmar arches were equally affected. Marked increase in arcuate vessels was noticed in nearly three-quarters of the patients, and in some, arcuate vessles were serving as collaterals. Histologically all sizes of vessles, including the capillaries, showed changes in nearly half the cases. Reflex vasodilation was lost in three cases of dimorphous leprosy and impaired or absent in three out of five cases of lepromatous leprosy. There was no predilection for any form of leprosy to show arterial changes more than the other. This study clearly demonstrates that the arterial involvement in leprosy is very frequent and must be playing an important role in causing mutilation and deformities of hands and feet.</p>  a0009-9260