01857nas a2200301   4500000000100000008004100001260001300042653002100055653003100076653001100107653003000118653001200148653001600160653002000176653001800196653001700214100001100231700001100242700001200253700001700265700001300282245007300295856007800368300000900446490000700455520107900462022001401541       1976                            d  c1976 Jan10aBlood Cell Count10aComplement System Proteins10aHumans10aImmune Adherence Reaction10aleprosy10aLymphocytes10aReceptors, Drug10aT-Lymphocytes10aTime Factors1 aSher R1 aHolm G1 aKok S H1 aKoornhof H J1 aGlover A00aT and CR+ lymphocyte profile in leprosy and the effect of treatment.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC420573/pdf/iai00217-0049.pdf  a31-50 v133 a<p>Thymus-derived lymphocytes (T lymphocytes) and complement receptor-bearing lymphocytes (CR+ lymphocytes) were estimated by using erythrocyte rosettes and erythrocyte-antibody-complement rosettes as markers in untreated lepromatous and untreated tuberculoid patients and in healthy controls. Treated lepromatous cases were also investigated. Ten cases of untreated lepromatous patients were reassessed 6 months or more after therapy commenced. A significant decrease in both percentages and absolute numbers of CR+ cells in the untreated lepromatous leprosy subjects was observed. This decrease showed a return to normal levels after treatment. The percentage of T cells in the untreated lepromatous cases was normal; however, the absolute numbers of T cells and the total lymphocyte count showed a significant decrease. After therapy, the T cell population was unchanged but the total number of lymphocytes increased significantly with treatment. The absolute number of T and CR+ cells was significantly less in the untreated than in the treated lepromatous patients.</p>  a0019-9567